Here, we demonstrate neuronal expression of IL-4Rα, the receptor co-chains IL-2Rγ (IL-4R type I) and IL-13Rα1 (IL-4R type II), as well as the type 2 immune cytokines IL-4 and IL-13 throughout the brain and spinal cord of healthy mice and of mice subjected to experimental autoimmune encephalomyelitis (EAE). Here, IL4 is linked to experimental autoimmune encephalomyelitis.