The baseline bone marrow miR-15a-5p, miR-20a-5p& miR-33b-3p expression levels were significantly decreased (0.29 ± 0.04, p < 0.001;0.42 ± 0.06, p < 0.001;0.51 ± 0.07, p = 0.02 fold-change relative to controls) in MM patients when compared to controls (1.04 ± 0.11,1.02 ± 0.07&1.05 ± 0.11;respectively) while EGR2 protein was significantly increased in MM patients when compared to controls. The gene discussed is EGR2; the disease is Miyoshi myopathy.