By using Kaplan − Meier survival test, the mean (95%CI) for OS was 24.08 (21.58–29.88) months throughout the 32-month follow-up period for MM patients, our results indicated that patients with lower expression levels of miR-15a-5p, miR-20a-5p&miR-33b-3p and higher expression level of EGR2 protein had poorer prognosis and possessing a shorter OS. Here, EGR2 is linked to Miyoshi myopathy.