Secondary endpoints include adverse-event rates, PSA response rates (proportion of patients with a decrease of 50% or greater in PSA level), biochemical progression-free survival (defined as the time until PSA level increases 25% and 2 ng/mL above the nadir), radiographic progression-free survival, and quality-of-life changes (measured using Functional Assessment of Cancer Therapy-Radionuclide Therapy and Brief Pain Inventory-Short Form). This evidence concerns the gene KLK3 and cancer.