Transcriptomic analyses of public datasets (TCGA and GTEx) revealed that both <i>CD74</i> and <i>Cathepsin L</i> (CTSL) are significantly overexpressed in diffuse large B-cell lymphoma (DLBCL) compared to normal tissues, and that their expression levels are highly correlated to each other (Spearman R = 0.64, <i>p</i> = 3 × 10<sup>-46</sup>). The gene discussed is CD74; the disease is diffuse large B-cell lymphoma.