When compared to age- and sex-matched controls, PD patients showed decreased concentrations of copper in the <i>substantia nigra</i> and other brain areas, a trend towards increased CSF and decreased serum/plasma copper levels, decreased serum/plasma ceruloplasmin levels, decreased zinc levels in serum/plasma and increased zinc in whole blood and hair, and increased hair manganese levels. Here, CP is linked to Parkinson disease.