Additionally, circRSU1 further enhances this process not only through increasing the hnRNPA1 protein level, but also through enhancing the interaction of hnRNPA1 with HIF1A IRES, consequently augmenting the CD24<sup>positive</sup> cell population and the associated malignancy/stemness features of HCC cells. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.