We first generated a "KPA" cell line by genetically deleting <i>Pik3ca</i> from a murine lung adenocarcinoma "KP" cell line harboring oncogenic <i>Kras</i> <sup><i>G12D</i></sup> and lacking <i>Trp53</i>. The gene discussed is PIK3CA; the disease is lung adenocarcinoma.