For the categorical outcome, the meta-regression analysis produced a boundary estimate (<i>τ</i> <sup>2</sup> = 0) with <i>I</i> <sup>2</sup>_res = 0% and a non-significant joint test (Prob > F = 0.3479); however, these findings are likely influenced by the limited number of studies and restricted degrees of freedom.<h4>Conclusion</h4>Serum FGF-23 levels are elevated in pediatric populations with cardiovascular disease, but study-specific thresholds have not shown a clear independent association with risk. The gene discussed is FGF23; the disease is cardiovascular disorder.