Children and adolescents with cardiovascular disease exhibited significantly higher serum FGF-23 levels compared to the control group [standardized mean difference [SMD] = 1.28, 95% confidence interval [CI] 0.53-2.03; <i>I</i> <sup>2</sup> = 93.0%], as determined using a random-effects model. The gene discussed is FGF23; the disease is cardiovascular disorder.