CCR5-defined CD8+ T-cell subsets also differed markedly, with subcortical infarction showing enrichment of CCR5+ effector cells, reduced checkpoint expression, and contraction of the CCR5− compartment.<h4>Discussion</h4>Peripheral immune remodeling in mild ischemic stroke displays clear infarct location-specific trajectories. The gene discussed is CCR5; the disease is ischemic stroke.