FCGBP and alkaline phosphatase measurement: In the third phase, functional validation was performed through: (i) in vivo experiments using a <i>Fcgbp</i>-knockdown mouse model demonstrated that reduced <i>Fcgbp</i> expression exacerbated AP severity and increased the risk of hemorrhage; and (ii) in vitro experiments with <i>FCGBP</i>-knockdown in human vascular fibroblasts showed that decreased <i>FCGBP</i> expression destabilized the vascular wall, leading to vascular injury in SAP.