Multi-gene co-mutations of &lt;i&gt;BRAF&lt;/i&gt; with &lt;i&gt;TERT&lt;/i&gt;, &lt;i&gt;PIK3CA&lt;/i&gt;, or &lt;i&gt;TP53&lt;/i&gt; are powerful predictors of central lymph node metastasis in papillary thyroid carcinoma. Here, TP53 is linked to differentiated thyroid carcinoma.