ADAM10 exists in an open, active conformation and a closed, auto-inhibited conformation, with the active form being more prevalent in tumor cells, providing a rationale for conformation-specific targeting.<h4>Methods</h4>To investigate the therapeutic potential of 1H5, cellular viability was assessed using viability assays, and ADAM10 dependency was evaluated by shRNA-mediated knockdown. This evidence concerns the gene ADAM10 and neoplasm.