Functional enrichment analysis showed that these genes were mainly enriched in negative regulation of cellular process, cytosol, response to organic substance, endpoint system, extracellar region, peroxisome proliferators-activated receptors (PPARs) signaling, adherens junction signaling, and DNA replication signaling pathway.<h4>Conclusions</h4>FOS and CCL2 may be involved in the molecular pathophysiology of muscle atrophy after SCI, serving as potential targets for diagnosis or treatment of SCI-related muscle atrophy. Here, CCL2 is linked to muscle atrophy.