Similar but less pronounced trends were observed in the EIE and EIE+A.<h4>Conclusion</h4>Within the limits of the current design, the combination of aerobic exercise with PD-L1 immune checkpoint blockade was associated with increased tumor-infiltrating CD4<sup>+</sup> and CD8<sup>+</sup> T-cell density and reduced tumor burden. This evidence concerns the gene CD4 and neoplasm.