Further, eight genes (<i>TMEM106C</i>, <i>BSG</i>, <i>COPE</i>, <i>CDCA8</i>, <i>KPNA2</i>, <i>LIG1</i>, <i>UQCRH</i>, and <i>CCT5</i>) with differential expression in HCC were applied to construct the risk model, which could stratify HCC patients into different risks and predict the prognosis. Here, TMEM106C is linked to hepatocellular carcinoma.