Patients with both risk factors had a significantly higher incidence of liver dysfunction than those in the other groups (p < 0.001).<h4>Conclusion</h4>Among patients aged ≥ 65 years, elevated baseline ALT (≥ 11 U/L) and CRP (≥ 5.9 mg/dL) levels were associated with an increased risk of CTRX-associated liver dysfunction. This evidence concerns the gene CRP and Decreased liver function.