Finally, cellular communication analysis of target immune cells was performed using bioinformatics approaches.<h4>Results</h4>rEg.P29 significantly alleviated OVA-induced histopathological changes in the lungs of mice with allergic asthma; downregulated serum IgE levels; reduced lung tissue eosinophils, Th2, and Th17 cells; and increased Th1 and Treg cells in mouse lung tissues. Here, IGHE is linked to allergic asthma.