IGHE and asthma: However, treatment response is heterogeneous, and traditional biomarkers, such as blood eosinophils, fractional exhaled nitric oxide (FeNO), and total serum IgE, may not fully explain this variability .<h4>Objective</h4>To evaluate clinical and inflammatory characteristics associated with response to biologic therapies in a real-world cohort of severe asthma patients.<h4>Methods</h4>A single-center, ambispective observational study was conducted in the Allergology Department of A Coruña, Spain.