SMAD4 and lung adenocarcinoma: Further, we investigated the role of sub-network motif in patient survival, hsa-miR-5010 was found to be significantly linked with patient outcome in Lung Adenocarcinoma (LUAD) (p = 0.033) and Lung Squamous Cell Carcinoma (LUSC) (p = 0.013) while SMAD4 (p < 0.001) and NRG1 (p < 0.001) expression exhibited prognostic significance in LUAD cohort only.<h4>Conclusion</h4>Our data indicated that NRG1-SMAD4-miR-5010-5p was the most prominent sub-network motif engaged in NSCLC patients based on the degree of centrality.