To ensure robustness, complementary MR approaches were performed, including pleiotropy-robust methods (MR-Corr and MRMix), multivariable MR adjusting for inflammatory biomarkers (C-reactive protein and interleukin-6), the robust adjusted profile score (RAPS) model, reverse MR, and colocalization analysis.<h4>Results</h4>MR analysis revealed a positive causal effect of ITP on depression (OR = 1.007, 95% CI: 1.001-1.013; p = 0.014), whereas no genetic predisposition of ITP on anxiety was observed. Here, IL6 is linked to major depressive disorder.