It could promote the production of short-chain fatty acids and regulate the relative abundance of T2DM-associated bacteria like <i>Muribaculaceae</i> and <i>Odoribacter</i>, and enhance hepatic glycogen synthesis through activation of the key gene involved in the PI3K/AKT/TBC1D4 pathway, resulting in hypoglycemic effect based on the gut-liver axis. The gene discussed is TBC1D4; the disease is type 2 diabetes mellitus.