A nomogram integrating CRRS and clinical variables achieved reliable prediction of 1-/3-/5-year survival (AUC > 0.72).<h4>Conclusion</h4>CYP4B1 functions as a tumor suppressor in LUAD, regulated by NFIA and exerting its effects through PI3K/AKT/mTOR pathway inhibition. This evidence concerns the gene NFIA and neoplasm.