Cytochrome P450 4B1 (CYP4B1), a lung-predominant enzyme, is linked to cancer susceptibility, but its role and regulation in LUAD remain unclear.<h4>Methods</h4>Multi-omics analyses of public datasets (TCGA_LUAD, GSE series) and clinical specimens assessed CYP4B1 expression. Here, CYP4B1 is linked to cancer.