A total of 16 mutations (<i>NF2</i>, <i>EGFR</i>, <i>EPHA2</i>, <i>CDK6</i>, <i>LATS2</i>, <i>NBN</i>, <i>CUL3</i>, <i>FRAS1</i>, <i>ATM</i>, <i>KMT2A</i>, <i>EXT1</i>, <i>SMARCA1</i>, <i>RECQL4</i>, <i>KMT2D</i>, <i>POLQ</i>, and <i>CTNND2</i>) were identified, and the tumor mutation burden was determined to be 5.73 mut/Mb via targeted gene sequencing. The gene discussed is POLQ; the disease is neoplasm.