IL6 and hepatocellular carcinoma: Interleukin-6 (IL-6), peripheral blood CD 8+ T cells, and prognostic nutritional index (PNI) can predict the response to immunotherapy.<h4>Conclusion</h4>In this study, we identify a novel signature based on TDEI genes that has the potential to be a biomarker for predicting the prognosis and immunotherapy response for HCC.