A network analysis identified a 16-gene hub (<i>CASP3</i>, <i>MAPK1/3</i>, <i>AKT1</i>, <i>STAT3</i>, etc.)underpinning effective drugs; curcumin targeted 14 of these nodes.<h4>Limitations</h4>Fifty-eight per cent of the data derived from rodent models revealed that these models do not menstruate and incompletely recapitulate human endometriosis. The gene discussed is CASP3; the disease is endometriosis.