CRP and Klebsiella pneumonia: Notably, a reversal in antibiotic susceptibility was observed: while the wild-type strain was sensitive to cotrimoxazole (inhibition zone: 22 mm), the CRP-overexpressing strain displayed complete resistance (inhibition zone: 7 mm).<h4>Conclusion</h4>Overexpression of CRP protein promotes biofilm formation and confers resistance to cotrimoxazole in bovine-derived <i>Klebsiella pneumonia</i>, indicating that CRP-mediated biofilm formation might be a key mechanism driving the observed cotrimoxazole resistance in this strain.