However, the molecular mediators driving this IFN signature and their utility as biomarkers remain incompletely defined.<h4>Methods</h4>We conducted an integrated multi-omics analysis combining plasma proteomics from 14 patients with DM and 5 healthy controls, with transcriptomic profiling of skeletal muscle derived from three publicly available Gene Expression Omnibus datasets (GSE11971, GSE1551, and GSE128470). This evidence concerns the gene IFNA1 and dermatomyositis.