TLR4 and Cognitive impairment: Protein expression related to the TLR4/MyD88/NF-κB pathway, neuroinflammation, cognitive impairment, synaptic damage, and neuronal apoptosis was analyzed through Western blotting.<h4>Results</h4>Combined therapy with 3-047 and ICT not only improved spatial learning and memory deficits in db/db mice but also modulated the expression of proteins associated with cognitive dysfunction.