However, the protection mechanism remains unclear.<h4>Objective</h4>To investigate the effect of SQC on INS-1 cell secretion and evaluate the associated mechanisms.<h4>Methods</h4>INS-1 cells were cultured in serum augmented with or without NOD1 inhibitor ML130 (2μM) for 1 h, then exposed into a high glucose (50 mM) condition to simulate type 2 diabetes mellitus (T2DM) for 24 h and treated with different concentrations (0, 5, 10, 15, 20%) of SQC in serum for another 24 h. The gene discussed is NOD1; the disease is type 2 diabetes mellitus.