We demonstrated here that IFN-γ/ LPS-primed MSCs alleviate schistosomiasis fibrosis through promoting conversion of Ly6C<sup>hi</sup>CX3CR1<sup>lo</sup> to pro-resolving Ly6C<sup>lo</sup>CX3CR1<sup>hi</sup>. The gene discussed is CX3CR1; the disease is schistosomiasis.