We analysed WGS data to assess the prevalence and spectrum of FH-causing variants.<h4>Methods</h4>Variants in <i>LDLR</i>, <i>APOB</i>, <i>APOE</i> and <i>PCSK9</i> were extracted from 100KGP WGS data and annotated using expert-reviewed ClinGen curation. Here, APOB is linked to familial hyperaldosteronism.