SDE2 and Miyoshi myopathy: This study investigated the role of SDE2, a ubiquitin-like protein overexpressed in MM, in modulating autophagy-ferroptosis crosstalk via ATG5 degradation with the aim of identifying novel therapeutic targets.<h4>Methods</h4>Using bioinformatic analysis of TCGA data, we identified SDE2 as a prognostic marker in MM.