This study investigated the role of SDE2, a ubiquitin-like protein overexpressed in MM, in modulating autophagy-ferroptosis crosstalk via ATG5 degradation with the aim of identifying novel therapeutic targets.<h4>Methods</h4>Using bioinformatic analysis of TCGA data, we identified SDE2 as a prognostic marker in MM. The gene discussed is ATG5; the disease is Miyoshi myopathy.