CHIP was also associated with incident events: Non-DNMT3A CHIP was associated with increased risk of time-to-HF hospitalization (HR 1.29 [95% CI 1.02-1.63], p = 0.03).<h4>Conclusions</h4>In high-risk individuals referred for cardiac catheterization, large CHIP and non-DNTM3A CHIP were associated with obesity, prevalent HF, incident CV events. The gene discussed is DNMT3A; the disease is obesity due to melanocortin 4 receptor deficiency.