Circulating proteomics with kidney transcriptomics were linked using data from an independent cohort of youth with obesity, with or without T2D, undergoing MBS in Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS, n = 64).RESULTSAfter VSG, participants lost weight and had improvements in insulin sensitivity and metabolic parameters. Here, INS is linked to type 2 diabetes mellitus.