,26 To investigate the impact of TFEB on KCs during MASLD, we generated KC-specific TFEB-overexpressing mice (KCTfeb) by crossing the Clec4fCre line (KCCre)11 with mice containing a flox/stop/flox cassette followed by a Tfeb–3×FLAG transgene21 (Figure 1A). Here, CALCA is linked to metabolic dysfunction-associated steatotic liver disease.