We deleted GDF15 in TFEB-TG animals (KCTfebGDF15fl/fl) (Supplemental Figure S5M, http://links.lww.com/HC9/C188), and after a HFHS diet, weight gain and hepatic steatosis were similar, indicating GDF15 also contributes to the reduction in hepatic steatosis with TFEB (Supplemental Figures S5N–P, http://links.lww.com/HC9/C188). The gene discussed is GDF15; the disease is fatty liver disease.