Sensitivity analyses were evaluated using Cochran's Q-test, MR-Egger regression, MR-PRESSO analysis, and leave-one-out analysis to assess the robustness and consistency of the results.<h4>Results</h4>Genetic predictions indicated a statistically significant association between transferrin saturation as the exposure and periodontitis as the outcome (OR=1.23, 95%CI: 1.08-1.41, p=0.002). This evidence concerns the gene TF and periodontitis.