Plasma levels of renin, angiotensin I (Ang I), angiotensin II (Ang II), angiotensin 1-7 (Ang 1-7), the Ang II/Ang I ratio (as a surrogate of ACE activity), and asymmetric dimethylarginine (ADMA)-a marker of endothelial dysfunction -were measured at baseline (D0) and day 3 (D3). This evidence concerns the gene ACE and endothelial dysfunction.