<h4>Objective</h4>This study aimed to investigate leptin (<i>LEP</i>) (<i>G</i>-2548A) and leptin receptor (<i>LEPR</i>) (668A>G) gene polymorphisms in schizophrenia patients with and without suicide attempts, compared to controls.<h4>Methods</h4>The study included 120 patients with schizophrenia and 130 healthy volunteers. This evidence concerns the gene LEP and schizophrenia.