Changes in specific IgE, IgG and IgG4 during SQ HDM SLIT-Tablet immunotherapy was assessed in 38 subjects with allergic asthma.<h4>Results</h4>HDM proteins were broadly immunogenic inducing comparable IgG, IgA, and non-TH2 cytokine responses in both allergic and non-allergic individuals. The gene discussed is IGHE; the disease is allergic asthma.