A case report by Hessel et al. found that switching from prazosin to doxazosin in a patient with PTSD and AUD did not result in a recurrence of PTSD symptoms (most recently nightmares and insomnia) in a patient admitted for AUD-associated pancreatitis, but they did not discuss the effects of alpha-1 antagonists on alcohol use [32]. The gene discussed is PSMA6; the disease is pancreatitis.