Another possibility for why the cross-lagged associations deviated from our expectations is recent evidence suggesting that only a subgroup of depressed patients exhibit a low-grade inflammatory state (i.e., CRP > 3.0 mg/L) [43], which supports the hypothesis that while inflammation may play a role in the onset of certain forms of depression, it may not universally apply to all manifestations of the disorder [104]. This evidence concerns the gene CRP and major depressive disorder.