Together with prior data showing an association between reduced plasma IgA and HIV-associated cryptococcal meningitis (CM), our findings suggest that the influence of human IgA on Cn pathogenesis warrants further investigation.IMPORTANCECryptococcal meningitis (CM) causes approximately 1,200,000 deaths annually in people living with HIV and is also a threat to individuals with non-HIV-associated immune-compromising conditions, such as organ transplant recipients and other patients receiving immunosuppressants. Here, CD79A is linked to cyclic hematopoiesis.