S100A4 and psoriasis: The role of S100A4, a key antimicrobial peptide, is highly expressed in psoriatic skin and has aroused considerable interest in recent years, yet its specific function and associated molecular mechanisms remain elusive.<h4>Methods</h4>Using CRISPR/Cas9 to generate S100a4 gene knockout mice, imiquimod was continuously applied to the back skin to induce the psoriasis disease model.