APLN and ischemic stroke: Recent studies indicate that mitochondrial biogenesis can improve ischemic stroke.<h4>Objective</h4>In this study, we aimed to investigate the effect of PIP combined with Apelin 13 on mitochondrial biosynthesis in IS and determine its mechanism and whether PIP promotes Apelin 13.<h4>Methods</h4>We used network pharmacology to screen chemical drugs for combination therapy for IS.