NLRP3 and asthma: At the same time, XBCQD restored the intestinal microbial species, and restored the beneficial bacteria such as <i>Dubosiella</i>, <i>Akkermansia_muciniphila</i>, <i>Rikenella</i>, which were reduced in obese asthmatic mice, and increased the content of acetic acid, propionic acid, and butyric acid in intestinal flora metabolites.<h4>Conclusion</h4>XBCQD regulates Th17/Treg immune imbalance in obese asthma by improving intestinal microecology and regulating SCFAs/GPR43/NLRP3 pathway.