<h4>Objective</h4>This study aimed to document changes in the urine protein-to-creatinine ratio (UPC) in dogs with inflammatory protein-losing enteropathy (iPLE) undergoing glucocorticoid therapy and with no overt evidence of concurrent renal disease.<h4>Methods</h4>Dogs with histologically confirmed iPLE, a serum albumin level of <2.0 g/dL, gastrointestinal signs for ≥2 weeks, and no recent glucocorticoid use were prospectively enrolled at any of the four referral centers between 24 December 2020 and 25 May 2023. The gene discussed is ALB; the disease is kidney disorder.