CD4 and cancer: Multivariate analysis showed that increased CD8<sup>+</sup>TCF1<sup>+</sup> cells (HR: 2.5; p=0.039) and increased TCF1 expression by cancer cells (HR: 2,7; p=0.041) in the TC and CD4<sup>+</sup>TCF1<sup>+</sup> cells (HR: 0.4; p=0.043) in the IF emerged as negative and positive independent prognostic markers for Disease-free survival (DFS), respectively.