CENPB and systemic lupus erythematosus: Compared with their anti-CENP-B-negative patients, anti-CENP-B-positive SLE patients displayed a markedly divergent therapeutic response.<h4>Conclusions</h4>Anti-CENP-B positivity defines a distinct SLE subset characterized by older age at onset, milder renal involvement, Raynaud's phenomenon, and specific humoral alterations; importantly, these patients also show a treatment response that differs significantly from that of the anti-CENP-B-negative group, underscoring the imperative for personalized, precision therapy.