Genetic silencing of <i>AADAT</i> in orthotopic murine TNBC models curtailed primary tumor growth and distant metastasis in a CD8<sup>+</sup> T-cell-dependent manner, enhanced effector T-cell activation, and sensitized tumors to dual PD-1/CTLA-4 blockade. The gene discussed is CTLA4; the disease is neoplasm.