SOST and chronic kidney disease: Predictive modeling identified <i>lncRNAs H19</i>, <i>MEG3</i>, and <i>MIAT</i> as significant predictors of hemodialysis status, while sclerostin, <i>MEG3</i>, and <i>MIAT</i> were the strongest predictors of CKD.<h4>Conclusion</h4>Serum sclerostin, lncRNAs (<i>H19</i>, <i>MEG3</i>, and <i>MIAT</i>), and microRNAs (<i>miR-135a</i> and <i>miR-29a</i>) are significantly interrelated and may serve as promising non-invasive molecular biomarkers for early detection and monitoring of CKD and hemodialysis patients.