This study aimed to evaluate the potential diagnostic significance and interrelationships of serum sclerostin, <i>lncRNA H19</i>, <i>lncRNA MEG3</i>, <i>lncRNA MIAT</i>, <i>miR-135a</i>, and <i>miR-29a</i> in patients with CKD and those undergoing hemodialysis.<h4>Methods</h4>A total of 150 participants were enrolled in this present case-control study: 50 hemodialysis patients, 50 CKD patients, and 50 healthy controls. Here, SOST is linked to chronic kidney disease.